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Everything you need to know about bioinformatics. Some of the most frequently asked questions are as follows:- Q.1. Where is the EMBL situated? Ans: The European Molecular Biology Laboratory is situated in Heidelberg, Germany. Q.2. What is FASTA? Ans: An alignment tool for protein sequences created by Pearson and Lipman in 1988. Q.3 . What is Fish? Ans: FISH (Fluorescence in situ hybridization) is a method, which is used to pinpoint the location of a DNA sequence on a chromosome. Q.4. How is HMM useful in bioinformatics? Ans: HMM (Hidden Markov Model) is a compute, algorithm which locates features which can distinguish a protein or gene family by analyzing a range of known sequences from the family. Q.5. What is a biological database? Ans: A biological database is a large, organized body of persistent data, usually associated with computerized software's designed to update queries and retrieve components of the dam stored within the system. Q.6. Which types of biological data are stored in biological databases? Ans: In general, biological database is a complex structure of many individual types of databases, collectively known as biological database and comprises nucleotide sequences, nucleotide structures, gene expressions data, protein structures, protein functions, metabolic pathways, cell type, cell signaling, tissues type, organs and organism type. Q.7. What are the main properties of a good database? Ans: A good database has following qualities: a. Broad coverage of the chosen topic, b. Up-to-date information gathering, c. Support staff, d. Commitment to the future, and e. Having good query interface. Q.8. What is the main function of biological databases? Ans: There are two main functions of biological databases, a. Provide biological data for research purpose to scientists, b. To make biological data available in computer readable form. Q.9. In which year, first biological sequence database was published? Ans: It was Atlas of Protein sequences and structure