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Frequently Asked Questions | ChemPep

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Fmoc-Glu(OtBu)-Thr(ψMe,Mepro)-OH, Formula C31H38N2O8; CAS [957780-56-2]

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THYMOSIN ALPHA 1 10mg ~ 99%> Purity, CAS NO: 62304-98-7,Thymosin α1 Article Talk Read Edit View history Tools Appearance hide Text Small Standard Large Width Standard Wide Color (beta) Automatic Light Dark From Wikipedia, the free encyclopedia PTMA Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes Identifiers Aliases PTMA, prothymosin, alpha, TMSA, prothymosin alpha External IDs OMIM: 188390; MGI: 97803; HomoloGene: 136511; GeneCards: PTMA; OMA:PTMA - orthologs Gene location (Human) Gene location (Mouse) RNA expression pattern Gene ontology Orthologs Species Human Mouse Entrez 5757 19231 Ensembl ENSG00000187514 ENSMUSG00000026238 UniProt P06454 P26350 RefSeq (mRNA) NM_001099285 NM_002823 NM_008972 RefSeq (protein) NP_001092755 NP_002814 NP_032998 NP_001347759 NP_001347760 Location (UCSC) Chr 2: 231.71 – 231.71 Mb Chr 1: 86.53 – 86.53 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse Thymosin α1 is a peptide fragment derived from prothymosin alpha, a protein that in humans is encoded by the PTMA gene.[5] It was the first of the peptides from Thymosin Fraction 5 to be completely sequenced and synthesized. Unlike β thymosins, to which it is genetically and chemically unrelated, thymosin α1 is produced as a 28-amino acid fragment, from a longer, 113-amino acid precursor, prothymosin α.[6] Function Thymosin α1 is an agonist for toll-like receptor 2 and toll-like receptor 9 on both myeloid and dendritic antigen-presenting cells, thereby stimulating the adaptive immune response.[7] Thymosin α1 is believed to be a major component of Thymosin Fraction 5 responsible for the activity of that preparation in restoring immune function in animals lacking thymus glands. It has been found to enhance cell-mediated immunity in humans as well as experimental animals.[8] Therapeutic application As of 2009 Thymosin α1 is approved in 35 under-developed or develop

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Activity: Measured in a cell proliferation assay using human umbilical vein endothelial cells (HUVEC). The ED50 for this effect is typically 4-16 ng/mL.

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