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Supporting you to pass your SCE in Acute Medicine 315+ questions Our questions are mapped to the Specialty Training Curriculum for Acute Internal Medicine, published by the Joint Royal Colleges of Physicians Training Board. <!-- split -->Demo Question   Which of the following may be responsible for a hypokalaemic hypertension?  Bartter's syndrome  Diabetic nephropathy   Liddle's syndrome  Non-classical congenital adrenal hyperplasia  Type IV renal tubular acidosis (RTA) <!-- split -->Key Learning Point   Liddle's syndrome is typically associated with hypokalaemic hypertension and low renin and aldosterone concentrations - the so-called pseudo-hyperaldosteronism.<!-- split -->Explanation   Liddle's syndrome is typically associated with hypokalaemic hypertension and low renin and aldosterone concentrations - the so-called pseudo-hyperaldosteronism. Bartter's syndrome is associated with hypokalaemia, though hypertension is not a feature. In type IV RTA, there is a hyporeninaemic hypoaldosteronism, which may also be produced with diabetic nephropathy, hence hyperkalaemia is more typical.