biosino.org Sitesinin İlk 10 Rakibi

cellagentech.com

PLX4032 (Vemurafenib) is an 7-azaindole-based, orally-available, inhibitor of the B-Raf V600E mutation with an IC50 of 30 nM. [1] In preclinical tumor models, PLX4032 induces antiproliferative effects in both mealonama and thyroid cell lines, with a simultaneous dose-dependent block of MEK1/2 phosphorylation. [1] Apoptosis is also observed in melanoma cell lines upon treatment with PLX4032. Important to note is that proliferation was inhibited in tumor cell lines expressing B-Raf V600E only, and not B-Raf WT or other B-Raf mutations. [2]PLX4032 has marginal effect on cell-cycle arrest, apoptotic cell changes, or alteration of phosphorylated signaling molecules in lymphocytes. T-cell function was preserved up to 10 uM of PLX4032, while cytotoxic activty was maintained up to high concentrations of 50 uM. [3] Such observations suggest that PLX4032 can be used in combination with immunotherapy strategies. Technical information: Chemical Formula:   C23H18ClF2N3O3S CAS #:   1029872-54-5, 918504-65-1 Molecular Weight:   489.92 Purity:   >98% Appearance:   White Chemical Name:   N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide Solubility:   Up to 100 mM in DMSO Synonyms:   PLX-4032, PLX4032, RG7204, RO5185426, Vemurafenib, Zelboraf Shipping Condition: The product is shipped in a glass vial at ambient temperature. Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC. Reference: 1. Yang et al., RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma models. Cancer Res. 2010, 70, 5518-5527. Pubmed ID: 20551065 2. Lee et al., PLX4032, a potent inhibitor of the B-Raf V600E oncogene, selectively inhibits V600E-positive melanomas. Pigment Cell Melanoma Res. 2010, 23, 820-827. Pubmed ID: 20973932 3. Comin-Anduix et al., The oncogenic BRAF k

jaspar.elixir.no

JASPAR is the largest open-access database of curated and non-redundant transcription factor (TF) binding profiles from six different taxonomic groups.

genomebc.ca

Genome British Columbia leads genomics innovation on Canada’s West Coast and facilitates the integration of genomics into society.

gramene.org

comparative plant genomics

ensemblgenomes.org

providing genome data for non-vertebrate species, with tools for the manipulation, analysis and visualisation of that data