nephjc.com Sitesinin İlk 10 Rakibi

theisn.org

Access cutting-edge research content, connect with a global community, grow professionally, and make a difference in kidney health with the International Society of Nephrology.

rrtjournal.biomedcentral.com

Background Brain death resulting from traumatic brain injury (TBI) can lead to significant changes in kidney function and morphology. Neutrophil gelatinase-associated lipocalin (NGAL) is a promising biomarker for early detection of acute kidney injury (AKI). This study aimed to evaluate urine NGAL levels in patients with brain death due to trauma and assess its relationship with kidney function and injury. Methods This prospective observational study included 63 patients diagnosed with brain death due to TBI. Urine NGAL levels were measured at 0, 12, 24, and 48 h after brain death diagnosis. Other parameters assessed included serum creatinine, glomerular filtration rate (GFR), and urine output. AKI was diagnosed on the basis of KDIGO 2012 criteria. Kidney biopsy was performed at 12 h, and histopathological damage was scored according to the Karpinski classification. Results Urine NGAL levels increased significantly over time after brain death (p < 0.05). Urine NGAL levels were significantly higher in patients who developed AKI compared with those without AKI at 0 h and 12 h (p < 0.001). At 0 h, urine NGAL had excellent predictive value for AKI with area under receiver operating characteristic (ROC) curve of 0.992 (95% CI 0.976–1.000, p < 0.001). At 12 h, urine NGAL maintained good predictive ability with AUC of 0.918 (95% CI 0.834–1.000, p < 0.001). Urine NGAL levels correlated positively with histopathological kidney damage scores at 12 h (p < 0.001). Conclusions Urine NGAL levels increase significantly after brain death due to trauma and show excellent predictive value for AKI in these patients. Urine NGAL may serve as an early and sensitive biomarker of kidney injury in patients with brain death being considered as potential organ donors.

nephsim.com

Below are a few nephrology calculators. Results from these calculators should be re-checked, and should not be used alone to guide patient care or solely inform clinical judgement. Filtration Fraction Rate of Fluid for Sodium Correction Fractional Excretion of X Free Water Clearance Serum Osmolality & Osmolal Gap Urine Osmolality & Osmolal Gap Free Water

kidneypathology.com

un sitio de patología renal para disfrutar los hallazgos microscópicos de las enfermedades renales que afectan al hombre. páginas relevantes en nefropatología, neoplasias renales, trasplante renal y mucho más. welcome to the magic world of nephropathology, glomeruli, podocites, interstituim and so on in kidney pathology. kidney disease, atlas and text.

kri.washington.edu

transforming lives through innovation and discovery