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f1000research.com

f1000research is an innovative open access publishing platform offering rapid publication and open peer review, whilst supporting data deposition and sharing.

scienceopen.com

Background Human lung mast cells (HLMCs) infiltrate the airway epithelium and airway smooth muscle (ASM) in asthmatic airways. The mechanism of HLMC adhesion to both cell types is only partly defined, and adhesion is not inhibited by function-blocking anti-Kit and anti-stem cell factor (SCF) antibodies. Our aim was to identify adhesion molecules expressed by human mast cells that mediate adhesion to human ASM cells (HASMCs) and human airway epithelial cells. Methods We used phage-display to isolate single chain Fv (scFv) antibodies with adhesion-blocking properties from rabbits immunised with HLMC and HMC-1 membrane proteins. Results Post-immune rabbit serum labelled HLMCs in flow cytometry and inhibited their adhesion to human BEAS-2B epithelial cells. Mast cell-specific scFvs were identified which labelled mast cells but not Jurkat cells by flow cytometry. Of these, one scFv (A1) consistently inhibited mast cell adhesion to HASMCs and BEAS-2B epithelial cells by about 30 %. A1 immunoprecipitated Kit (CD117) from HMC-1 lysates and bound to a human Kit-expressing mouse mast cell line, but did not interfere with SCF-dependent Kit signalling. Conclusion Kit contributes to human mast cell adhesion to human airway epithelial cells and HASMCs, but may utilise a previously unidentified adhesion domain that lies outside the SCF binding site. Targeting this adhesion pathway might offer a novel approach for the inhibition of mast cell interactions with structural airway cells, without detrimental effects on Kit signalling in other tissues.

ijrar.org

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globalhealth.unc.edu

ACADEMIC YEAR FALL 2025-SPRING 2026 December 5, 2025 Dr. Geri Donenberg – CFAR World Aids Day Symposium  November 14, 2025 Jonathan S. Serody, MD – Adoptive Cellular Therapy for Cancer: The Good, The Bad, and the Future November 7, 2025 Geetanjali Chander, MD, MPH, Alexis Vien, MD, Heidi Hutton, PhD – Unhealthy Alcohol Use Among … Read more

csescienceeditor.org

Introduction Equal access to web content is long overdue. Publishers must ensure that content is accessible to people who are blind, deaf, neurodivergent, color blind, lack contrast sensitivity, or who use tools other than a mouse to operate their computer. I am a user experience designer and a former web developer. As a developer, I spent years coding accessible content for U.S. government websites. This article will identify some coding conventions that will make websites more accessible.  Publishers can begin to address the needs of all users with coding conventions that make websites more accessible. These efforts will be furthered by an understanding of how people navigate the web with screen readers, and an awareness of how different people view color. This article will focus on strategies around color and for screen readers.  Test Your Site Without Using a Mouse As a first step in reviewing a website for accessibility, consider that some people navigate websites without a mouse. A customer with quadriplegia may use a mouth-operated controller, and a reader with a broken arm may tab through a website.  It’s easy to test a website without a mouse and it’s critically important to do so. Tab through all of the elements and make sure that all parts of the navigation, all form fields, and all other elements can be accessed without a mouse. Elements that cannot be accessed without a mouse should be recoded to make them accessible.   Screen Readers A screen reader is a software program that reads […]

anthroencyclopedia.com

Racism is premised on the idea that humanity could and should be divided into distinct biological groups or ‘races’, and that different races stand in a ranked and hierarchical relation to one another. Racism understands human races to be separate and clear-cut clusters of people, based on biological criteria that are fixed and relevant for their behavior. While humans do vary biologically, their variation does not fall into such clusters that correspond to racial categories. Speaking of human races thus ignores the contemporary science of human variation, whilst intimately mixing the study of human biology with hierarchy, stigma and prejudice. As a worldview, racism was historically pervasive in the academy and in anthropology, a discipline that emerged in the context of colonialism, colonial discovery, and the exploration of human diversity. While the concept of race was in many respects foundational to the development and practice of anthropology it is now contested. As we will discover in this entry, the concepts and definitions of race, and their applicability, have changed greatly over time. Drawing on ethnographic material from various social and political contexts, and attempts at theorising race and racism, this entry will discuss important ways in which anthropologists have shaped both concepts in the past and in the present. Their work contributes to the important insight that race is not biologically but socially constituted. ‘Race is the child of racism, not the father’ (Coates 2015, 7).

autoimmuneinstitute.org

An artist reflects on living with chronic autoimmune and neurological illnesses, and how music, leadership, and creative identity adapt and endure.