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dna20.com

ATUM Discover the world of advanced bioengineering with ATUM – your life science partner! Integrated solutions accelerate timelines from discovery to

addgene.org

addgene, the nonprofit plasmid repository, accelerates science by sharing useful plasmid-based research materials, viral preps, and information worldwide.

primesyn.com

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celprogen.com

Overview Publication Documents Product Description Exosomes are small, single-membrane, secreted organelles of ∼30 to ∼200 nm in diameter that have the same topology as the cell and are enriched in selected proteins, lipids, nucleic acids, and glycoconjugates. Exosomes contain an array of membrane-associated, high-order oligomeric protein complexes, display pronounced molecular heterogeneity and are created by budding at both plasma and endosome membranes. Exosome biogenesis is a mechanism of protein quality control, and once released, exosomes have activities as diverse as remodeling the extracellular matrix and transmitting signals and molecules to other cells. This pathway of intercellular vesicle traffic plays important roles in many aspects of human health and disease, including development, immunity, tissue homeostasis, cancer, and neurodegenerative diseases. In addition, viruses co-opt exosome biogenesis pathways both for assembling infectious particles and for establishing host permissiveness. On the basis of these and other properties, exosomes are being developed as therapeutic agents in multiple disease models. How they are used in medicine Regenerative medicine: Exosomes derived from stem cells are being used to promote tissue repair, such as in wound healing and regenerating damaged tissue. Cosmetic applications: They are used in skincare to improve skin texture, elasticity, and collagen production, often delivered via serums or applied after procedures like microneedling. Cancer therapy: Researchers are exploring their use in cancer vaccines and as a way to deliver anti-cancer drugs. What Exosomes do Intercellular communication: Exosomes transmit signals and molecules from one cell to another, influencing the function of the recipient cell. Disease involvement: They are implicated in the progression of diseases such as cancer and neurodegenerative disorders. They can spread cancer-promoting molecules and even drug resistance between cells. Th

excellgene.com

Discover cutting-edge CHO and HEK293 manufacturing solutions. Accelerate and de-risk recombinant biologic drug development with our high-yield, fast, and scalable production technologies.

genaxxon.com

The Legionella Detection Multiplex qPCR Assay is designed to target specific and unique DNA sequences within the Legionella genome. The PCR products from 4 different reactions can be detected by specific DNA probes labeled with 4 different fluorophores. This allows the simultaneous detection of all the Legionella species associated with infection, all the L. pneumophila serogroups (1-16) and specifically identifies L. pneumophila sg-1, responsible for ~95% human infections. An internal amplification control is also included in the master mix as an indicator that the PCR is functioning correctly. Designed to work on the leading real-time PCR platforms, Bio Lp-1 rapidly detects extremely low levels of Legionella, and can differentiate between Legionella spp, all L. pneumophila serogroups 1-16 and L. pneumophila-serogroup 1 simultaneously in a single water sample, giving a complete and accurate Legionella profile. With this certainty, the exact risk to public health can be quickly determined and acted upon. Particularly beneficial in cases of an outbreak, appropriate remedial actions can be taken, their efficacy monitored to reduce and remove Legionella bacteria from a contaminated water system. In less than 5 hours, water quality and safety can be assured. Simple and convenient to use, and in a freeze-dried format, the test contains all necessary components to process a water sample directly. Bio Lp-1-Legionella multiplex one step qPCR Kit is a diagnostic breakthrough, being the world’s first open platform rapid NAD kit for simultaneously detecting and identifying multiple species of Legionella from water in a single test. The lyophilized master mix is aliquoted into 12 x 8 low profile qPCR strips (foil wrapped). This kit comes with negative and positive DNA control enabling to prepare standards of 10E5 GU, 10E4 GU, 10E3 GU, 10E2 GU, 10E1 GU (with 1 GU = one genomic unit).

geneservice.co.uk

an overview of the science of genetics and the study of hereditary