Top 10 darahjournal.org.sa Competitors

zujournal.zu.edu.jo

مجلة الزرقاء للبحوث والدراسات الإنسانية (zu journal)

immunenetwork.org

Immune Network

jmchemsci.com

This research is dedicated to investigating the bioactive compounds of the Paraboea leuserensis B.L. Burtt ethyl acetate fraction as potential beta-secretase 1 (BACE1) inhibitors, a central enzyme in amyloid beta (Aβ) peptide production that oligomerizes to create neurotoxic Alzheimer's disease plaques. Since BACE1 is a central enzyme in the amyloidogenic pathway, enzyme inhibition presents a promising therapeutic approach to delaying or even preventing the development Alzheimer's disease. Phytochemical analysis of the extract provides evidence of high phenolic acid and flavonoid content, two classes of secondary metabolites well known for their neuroprotective potential. In vitro assays illustrate that the extract significantly suppresses the activity of BACE1, a marker that renders the natural product pharmacologically active as a preventive agent for neurodegenerative disorders. To further improve the bioavailability and effectiveness of such bioactive molecules, an alternative nanophytotherapy strategy based on nanoparticle formulation has also been explored. The work here opens up new avenues to explore the use of Paraboea leuserensis as a source of a therapeutic candidate and forms the basis for future studies on identifying active constituents and determining molecular mechanisms of action.

saudipedia.com

是一套数字百科全书，发布关于沙特阿拉伯的所有内容。本地化的内容，可以供任何人使用。由沙特新闻部发起，作为国家参考和文档来源。它保留其书面和视听内容的版权及所有权，并定期更新和修订。

araa.sa

مجلة شهرية معنية ومتخصصة بشؤون منطقة الخليج وقضاياها والتحديات والمخاطر التي تواجهها، وكذلك القضايا الاستراتيجية وقضايا التنمية المستدامة بمعناها الشامل، وأيضاً معنية باستقرار وأمن منطقة الخليج.