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neuromics.com

proven reagents for results you trust and understand. neuromics provides a range of solutions for the discovery of new therapies, target identification and confirmation, toxicology studies, gene silencing and amplification, and 2-d/3-d cell-based assays. neuromics serves most pharmaceutical companies, biotech's, and academic/government labs. neuromics reagents cover various areas of research, including neuroscience, cell biology, cancer research, immunology, drug discovery, and regenerative medicine. our products cater to researchers working in diverse scientific disciplines.

protocol-online.org

database of research protocols in bioscience including molecular biology, cell biology, immunology, plant biology, developmental biology, neuroscience, bioinformatics, genetics, etc. also hosts discipline-specific discussion forums and provides free pubmed alerting service

medsci.cn

medsci(梅斯医学)致力于医疗质量的改善，从事临床研究服务、数据管理、医学统计、临床培训、继续教育等支持，促进临床医生职业发展和医疗智慧化。

jneurosci.org

While transient changes in synaptic strength occurring during the repetitive firing of primary afferent inputs to the spinal superficial dorsal horn (SDH) are predicted to strongly influence the fidelity with which nociceptive signals are transmitted through the SDH network, little is known about whether the properties of short-term plasticity (STP) at sensory synapses depend on the identity of the postsynaptic target or whether STP is under the control of neuromodulators such as dopamine. Here we investigate these issues using ex vivo patch-clamp recordings from identified lamina I spinoparabrachial neurons, inhibitory interneurons (VGAT+), and putative excitatory interneurons (VGAT−) in spinal cord slices from adult mice of both sexes. Repeated activation of A-fiber inputs to the SDH evoked short-term depression (STD) across all major subtypes of SDH neurons, although the magnitude of STD was greatest in projection neurons with high-frequency stimulation. Meanwhile, repetitive activation of C-fiber synapses onto GABAergic interneurons evoked more pronounced STD compared with excitatory neurons across a range of stimulation frequencies. Both A-fiber and C-fiber synapses recovered from STD at a similar rate across the different SDH cell types examined. Dopamine (20 µM) significantly depressed the overall glutamatergic drive, and reduced afferent-evoked firing, selectively in spinoparabrachial neurons and excitatory interneurons without changes in the properties of STP. Collectively, these findings reveal novel potential mechanisms by which the efficacy of the spinal inhibitory “gate,” and thus the gain of ascending nociceptive transmission to the brain, may be rapidly altered during periods of strong sensory input to the SDH network.

nlm.nih.gov

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