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translational-medicine.biomedcentral.com

Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex disorder characterized by persistent fatigue and cognitive impairments, with emerging evidence highlighting the role of gut health in its pathophysiology. The main objective of this review was to synthesize qualitative and quantitative data from research examining the gut microbiota composition, inflammatory markers, and therapeutic outcomes of interventions targeting the microbiome in the context of ME/CFS. Methods The data collection involved a detailed search of peer-reviewed English literature from January 1995 to January 2025, focusing on studies related to the microbiome and ME/CFS. This comprehensive search utilized databases such as PubMed, Scopus, and Web of Science, with keywords including “ME/CFS,” “Gut-Brain Axis,” “Gut Health,” “Intestinal Dysbiosis,” “Microbiome Dysbiosis,” “Pathophysiology,” and “Therapeutic Approaches.” Where possible, insights from clinical trials and observational studies were included to enrich the findings. A narrative synthesis method was also employed to effectively organize and present these findings. Results The study found notable changes in the gut microbiota diversity and composition in ME/CFS patients, contributing to systemic inflammation and worsening cognitive and physical impairments. As a result, various microbiome interventions like probiotics, prebiotics, specific diets, supplements, fecal microbiota transplantation, pharmacological interventions, improved sleep, and moderate exercise training are potential therapeutic strategies that merit further exploration. Conclusions Interventions focusing on the gut-brain axis may help reduce neuropsychiatric symptoms in ME/CFS by utilizing the benefits of the microbiome. Therefore, identifying beneficial microbiome elements and incorporating their assessments into clinical practice can enhance patient care through personalized treatments. Due to the complexity of ME/CFS, which involves genet

scientificscholar.com

Scientific Scholar is a publishing company established with the aim of publishing peer-reviewed scientific journals. Scientific Scholar's mission is Share, Learn and Improve

actscience.org

Join the ACTS Evaluation Special Interest Group  webinar entitled “Collaborating to Grow Learning Health Systems: Developing a Framework for Return on Investment .” View Webinar View Slides  What are the benefits achieved for stakeholders when an organization adopts a learning health system (LHS) model? In May 2021, evaluators and process improvement experts from six Clinical and Translational Science Award (CTSA)-affiliated institutions initiated a workgroup...

bmjopen.bmj.com

BMJ Open is a leading multidisciplinary open access medical journal publishing high-quality peer-reviewed content.

ijpbs.com

the international journal of pharmacy and biological sciences (ijpbs) is a scholarly publication ugc approved journal of best quality that focuses on the latest research and advancements in the fields of pharmacy and biological sciences. it serves as a platform for scientists, researchers, academicians, and professionals to share their original contributions, scientific discoveries, and innovative ideas.

platform.who.int

The United Nations agency working to promote health, keep the world safe and serve the vulnerable.

globalhealthprojects.org

Family Tree Adoption Program (FTAP) provides free native trees to Prince George’s County homeowners, helping beautify yards and build greener communities.

pubmed.ai

Learn how to search peer-reviewed biomedical literature with PubMed.ai. Discover tips for keyword queries, filters, and research-focused search strategies.

mchandaids.org

Background and Objective: Human Immunodeficiency Virus (HIV) care programs in resource-limited settings reserve counseling and referral for individuals with identified mental illness for those with HIV virological treatment failure (VTF). Adolescence is a period that may increase the likelihood of internalizing psychiatric disorders (IPDs). We assessed the relationship between HIV VTF and symptoms of IPDs among adolescents and young adults (AYA) living with HIV in Gaborone, Botswana. Methods: A cross-sectional study was conducted in Botswana from December 2018 to December 2019 among AYA living with HIV aged 12–24 years. Logistic regression analysis was used to examine relationships between age, sex, and HIV VTF (≥400 copies/mL) and clinically relevant IPD symptoms, namely, depression (Patient Health Questionnaire-9 score of ≥10) and anxiety (Generalized Anxiety Disorder-7 score of ≥10). Results: Of 553 participants, most were aged 16–19  years (53%) with an equal sex distribution; the minority had VTF using HIV viral load (VL) cutoff levels of ≥400 copies/mL (11%). Close to one-sixth (15%) had clinical depression symptoms; participants aged 16–19 years and 20–24 years were more likely to have clinically relevant depression symptoms when compared to participants who were aged 12–15 years (odds ratio [OR] 3.160, 95% confidence interval [CI] 1.094–9.123 and OR 4.748, 95% CI 1.624–13.877, p = 0.0117, for participants aged 15– 19  years and 20–24  years, respectively). Participants with clinically relevant anxiety symptoms (11%) or both clinically relevant anxiety and depression symptoms (8%) did not differ from those without these symptoms by age, gender, or VTF status. Similar results were observed using HIV VL cutoff levels of