Top 10 yearbook.stpi.org.tw Wettbewerber

gibmt.tmu.edu.tw

graduate institute of biomedical materials & tissue engineering

cgp.iiarjournals.org

Background/Aim: Cancer remains a leading cause of mortality globally, driven by complex molecular mechanisms and characterized by significant biological heterogeneity across cancer types. We aimed to discover mitogen-activated protein kinases (MAPKs) family members as both biomarkers and therapeutic targets in different cancer types. MAPKs are key signaling molecules regulating cell proliferation, differentiation, stress response, and apoptosis. Dysregulation of MAPK pathways has been implicated in the onset and progression of multiple cancers, contributing to tumor growth, metastasis, and therapeutic resistance. Given their diverse roles across cancer types, systematic analysis of MAPK gene expression, mutations, and interactions with tumor microenvironment is essential. Materials and Methods: The present study undertakes a comprehensive transcriptomic analysis of MAPKs in nine major cancer types using RNA-Seq datasets from The Cancer Genome Atlas (TCGA). RNA-Seq data were analyzed to identify differentially expressed MAPKs across nine cancer types using DESeq2, NOIseq, and limma. Significant genes (adjusted p <0.05) were subjected to GO and KEGG enrichment (EnrichR), mutational profiling (cBioPortal), and Kaplan-Meier survival analysis. Tumor immune infiltration was further assessed using TIMER2.0 to explore immune–gene interactions. Results: Through rigorous differential expression analysis, we identified key MAPKs that are significantly altered in liver hepatocellular carcinoma (LIHC) and lung adenocarcinoma (LUAD). Specifically, six MAPKs (MAPK3, MAPK7, MAPK9, MAPK10, MAPK12, and MAPK13) were found to be differentially expressed in LIHC, while MAPK6 emerged as the sole significant candidate in LUAD. Functional enrichment and pathway analysis revealed that these MAPKs are involved in critical oncogenic pathways, including MAPK-mediated transcriptional regulation and stress-activated signaling cascades. Mutational profiling and survival analysis further validat

atm.ncu.edu.tw

國立中央大學大氣科學學系

gbimonthly.com

華文界唯一紙本與數位並行的專業生技醫藥產業媒體。掌握大中華生技市場脈動，亞洲專業華文生技產業月刊。