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medicalview.co.jp

メジカルビュー社は1968年（昭和43年）創業の医学書専門の出版社です。

ijcce.ac.ir

Diabetic Nephropathy (DN), a major complication of diabetes mellitus, is a leading cause of end-stage renal disease worldwide. This study explores the therapeutic potential of rutoside (rutin) in combating DN using a streptozotocin (STZ)-induced diabetic rat model. Additionally, we conducted mechanistic evaluations to elucidate the underlying pathways involved in rutin-mediated renoprotection, focusing on network pharmacological analysis and molecular interactions through in silico molecular docking studies, and experimental validation of its antioxidant and anti-inflammatory effects. A network pharmacological approach was used with the initial screening of the pharmacokinetic properties of rutin and toxicity evaluation, which indicated low GI absorption with a bioavailability value of 0.17 and no major toxicity associated with the rutin molecule. Target prediction revealed 97 biological targets of rutin and 858 targets of diabetic nephropathy; among these 35 targets were found to be common between rutin and diabetic nephropathy, and these targets have a significant probability in the pathogenesis of the disease. A Protein-Protein Interaction (PPI) network of these common targets was constructed to identify linkages between the different protein targets. Identification of hub genes and Gene Ontology (GO) and KEGG enrichment pathways was also carried out to demonstrate the involvement of different genes, and their functions, besides the signalling pathways, and how these pathways are connected with diabetic nephropathy. Three target proteins, including MTOR, PIK3R1, and NFKB1, were identified by network pharmacology to be the most closely related protein targets to DN and were subjected to in silico molecular docking analysis to identify key molecular interactions and the involved amino acid residues of the targets. Rutin treatment exhibited a considerable hypoglycaemic index in comparison to the diabetic group. Treatment with rutin also led to a substantial reductio

wvencyclopedia.org

The prehistoric Adena culture developed with the beginnings of horticulture about 2,500 years ago within the Ohio River Valley and along major tributaries such as the Kanawha, Scioto, and Kentucky ...

fundinguniverse.com

company profiles, page 1

giurcost.org

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esamskriti.com

esamskriti: an online encyclopedia of indian culture, indian traditions, ancient india, education in india, history of india, indian travel, indian leaders, festivals of india, languages, ayurveda, & many more…

reflexionesmarginales.com

Lo marginal es un concepto relacional: aparentemente relegado a las orillas de lo establecido, se trata de una condición asociada a lo subterráneo, a menudo también a lo clandestino; en todo caso a lo oculto, aquello que crece a la saga y a la sombra de los grandes temas y circunstancias que redondean el ideario...

namediscoveries.com

Discover the meaning behind the world's greatest names.

ggarchives.com

Since 2000, the Gjenvick-Gjønvik Archives, or GG Archives, has helped genealogists, family historians, and researchers worldwide provide a more complete social and cultural context of their family history or historical research. Students, Researchers, Historians, Teachers, and Others have utilized our images, documents, and reports for over 24  years.