Top 10 cancerres.aacrjournals.org Competitors

ard.bmj.com

Archive of Annals of the Rheumatic Diseases, a leading rheumatology journal previously published by BMJ.

oncotarget.com

Subscribe to Oncotarget email alerts for new articles, press releases, and journal updates in oncology and cancer research.

ar.iiarjournals.org

Background/Aim: T-cell receptor recombination sequencing reads have been extracted from genomics files and have been characterized and correlated with patient outcomes for many different cancer types. Materials and Methods: An immunogenomics approach was applied to endemic Burkitt lymphoma (BL) utilizing the Cancer Genome Characterization Initiative – Burkitt Lymphoma Genome Sequencing Project (CGCI-BLGSP), focusing on TCR V- or J- gene segment, HLA allele combinations and anti-HIV CDR3s. Results: Results indicated that five TCR V- or J- gene segment, HLA allele combinations were associated with overall survival (OS) distinctions where the individual arms of the combinations were not associated with survival. Anti-HIV analyses indicated that those cases with an anti-HIV TRA CDR3 had a higher OS probability than those without (median OS not reached vs . 215 days; log-rank p =0.0013), and those with anti-HIV TRA and TRB CDR3s had better pathologic staging compared to those without. Conclusion: T-cell response leads to early control of progression of endemic BL.

academic.oup.com

Oxford Academic

sciencedirect.com

sciencedirect is the world's leading source for scientific, technical, and medical research. explore journals, books and articles.

pubmed.ncbi.nlm.nih.gov

Bill & Melinda Gates Foundation.

ncbi.nlm.nih.gov

Search all biomedical databases provided by the National Center for Biotechnology Information (NCBI), an agency of the U.S. National Library of Medicine at the NIH

biorxiv.org

biorxiv - the preprint server for biology, operated by cold spring harbor laboratory, a research and educational institution