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ijabbr.com

Targeted protein degradation (TPD) represents a paradigm shift in drug discovery, offering a novel therapeutic strategy to selectively eliminate disease-causing proteins rather than merely inhibiting their function. This review comprehensively explores the mechanistic landscape of TPD, detailing the ubiquitin–proteasome system (UPS), lysosomal degradation pathways, and the rationale behind catalytic degradation surpassing traditional inhibition. The design principles of proteolysis-targeting chimeras (PROTACs), including their bifunctional architecture, E3 ligase recruitment, and ternary complex formation, are discussed alongside clinical-stage examples. Emerging modalities such as molecular glues, LYTACs, AUTACs, and photo-switchable degraders are also examined. TPD modalities expand the degradable proteome by addressing intracellular, extracellular, and RNA targets. Therapeutic applications span oncology, neurodegeneration, autoimmune, and infectious diseases, demonstrating the potential of TPD to overcome drug resistance and target previously “undruggable” proteins. Integration with precision medicine and immunotherapy highlights synergistic clinical potential. Despite its promise, TPD faces challenges including bioavailability, tissue penetration, resistance mechanisms, and E3 ligase limitations. Advances in artificial intelligence/machine learning, CRISPR screening, and chemoproteomics are enabling next-generation degrader design, paving the way for programmable and personalized therapies. Collectively, these developments position TPD as a transformative platform poised to revolutionize future drug development.

ijche.com

The rapid growth in global demand for clean and sustainable energy has intensified the need for efficient hydrogen (H2) production technologies. Thermochemical recycling of plastic waste has emerged as a promising approach, offering both environmental benefits and the generation of high-purity, low-carbon H2. This study evaluates the technical and economic feasibility of H2 production from diverse plastic waste streams using Aspen HYSYS and the Aspen Economic Analyzer. The process integrates polymer pyrolysis, chlorine removal, and steam reforming. Feedstocks (200×10³ t/y) include polyethylene (PE), polypropylene (PP), polyvinyl chloride (PVC), polystyrene (PS), polyethylene terephthalate (PET), and mixed industrial and municipal waste from packaging (PKG), medical (MED), automotive (AUT), municipal solid waste (MSW), construction (CON), and textile (TEX) sectors. H2 production yield strongly depends on the feedstock composition, ranging from 0.14 to 0.31 t H₂/t feed. PET with the lowest H/C ratio, exhibits the lowest yield, whereas PE and PP achieve the highest yields, albeit with incomplete carbon-to-CO conversion. Oxygenated polymers, such as PET, generate the highest CO2 emissions (~1.4 t/t feed). Economic analysis indicates that PE and MED are the most cost-effective feedstocks, with gross margins of 62 and 66% and annual net profits of 232×10⁶ and 223×10⁶ USD, respectively.

cem.de

Beratung zu Laborsystemen. Bearbeiten von Proben, Übersicht von Mikrowellen-Laborgeräten, Aufschluss-Geräte, Mini Gas-Chromatographie, HPLC, Lösemittel-Extraktion.

cnqzu.com

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aqa.org.ar

asociación química argentina