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solutions.springernature.com

Springer Nature Research Solutions will help you on your path to accelerating publication, nurture your career in scientific research, and expand your research's reach beyond peers.

jneuropsychiatry.org

Neuropsychiatry Journal publishes peer-reviewed open-access studies on brain disorders, mental illness, neurodegeneration, imaging, psychiatry, and clinical neuroscience.

psychiatry-psychopharmacology.com

Background: In this study, the relationship between treatment response, clinical features of episodes such as psychosis, suicidal behavior, and agitation, duration of hospitalization, and systemic inflammation markers Systemic Inflammatory Index (SII), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) in bipolar affective disorder manic episode (BAD-M), bipolar affective disorder—depressive episode (BAD-D), and major depressive disorder (MDD) were investigated. Methods: The NLR, MLR, PLR, and log SII were measured using parameters from a complete blood count. Admission and discharge Young Mania Rating Scale and Hamilton Depression Rating Scale scores were evaluated. This is a retrospective study conducted with a total of 451 inpatients, 122 (27.10%) of whom were diagnosed with BAD-M, 60 (13.20%) with BAD-D, and 269 (56.60%) with MDD. Results: The patients with manic episodes have higher levels of NLR (P=.019), MLR (P=.002), and log SII (P=.007). In the bipolar depression and mania groups, the patients with and without treatment responses did not differ in terms of inflammation markers; the log PLR value was found to be higher in the unipolar depression group in the patients who did not reach remission (P=.048). Conclusion: This study reveals associations between inflammation markers and different types of mood episodes. Higher NLR, MLR, and log SII levels in bipolar mania and lower NLR levels in agitated unipolar depression provide clues about changes in inflammation across different episodes. Studies with larger samples are needed to evaluate the relationship between inflammatory markers, the severity of mania and depression, and the response to treatment. Cite this article as: Kucukkarapinar M, Erbil D, Keles İ, Karadag F. Association between mood disorder severity, treatment response and systemic inflammatory markers: Exploring the role of NLR, PLR, MLR, and SII. Psychiatry Clin Psychopharmaco

hema101.com

HEMA is hard. HEMA 101 makes it easier by providing intuitive explanations of historical fencing systems and techniques. This blog will contain guides for various HEMA systems.

nbiadisorders.org

the nbia disorders association is your number 1 resource for education, advocacy, research news and family support for neurodegeneration with brain iron accumulation (nbia) disorders.

medsciencegroup.us

Maximising locomotor independence following stroke remains a central goal of neurorehabilitation. Traditional manual techniques, while foundational, are insufficient to fully restore locomotion independence. This paper offers an interpretation of published evidence regarding post-stroke rehabilitation and advocates for a construct of hypothesis-driven approach combined with clinical observation that integrates readily accessible, technology-based precision training designed primarily to target the paretic lower extremity. It emphasises using technologies capable of both assessment and collection of objective performance data over time, advocates for individualised intervention derived from each patient’s baseline locomotion measurements and stresses the need for a quantitative, outcome-driven training program aimed at recovering less dependent locomotion ability. The paper proposes a practical definition and description of independent and dependent locomotion and explores common barriers to recovering independence in locomotion post-stroke. It presents the rationale and mechanisms that govern the selection of therapeutic technologies, including functional electrical stimulation (FES), treadmills, and motorised plinth/tables that hypothetically support recovery of locomotion. The proposed novel composition of precision locomotion training and the added value of incorporating effective and efficient hybrid technologies are highlighted as critical to the recovery of locomotion ability in post-stroke rehabilitation.