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aaaai.org

website of the aaaai. medical content developed and reviewed by the leading experts in allergy, asthma and immunology.

allergyasthmanetwork.org

This Webinar was recorded on June 10th, 2026 Effective management of allergy and asthma conditions often requires a coordinated, team-based approach to address complex clinical needs and improve…

aacijournal.biomedcentral.com

Allergic rhinitis (AR) is the most common undiagnosed chronic condition in children. Moderate/severe AR symptoms significantly impair quality of life, and cause sleep disruption, absenteeism and decreased productivity. Additionally, untreated AR predisposes children to asthma and other chronic conditions. Although intranasal corticosteroids are the most effective pharmacologic treatment for AR, oral antihistamines are often preferred. First-generation antihistamines may be chosen to relieve AR symptoms as they are inexpensive and widely available; however, they cause sedative and cardiovascular negative effects due to poor receptor selectivity. Therefore, second-generation antihistamines were developed to reduce adverse effects while retaining efficacy. There are fewer clinical trials in children than adults, therefore, efficacy and safety data is limited, particularly in children under 6 years, highlighting the need to generate these data in young children with AR. Fexofenadine, a highly selective second-generation antihistamine, effectively alleviates symptoms of AR, is non-sedating due to decreased blood–brain barrier permeability, and is devoid of cardiovascular side effects. Importantly, fexofenadine relieves the ocular symptoms of allergic conjunctivitis, which occur concomitantly with AR, improving quality of life. Overall, fexofenadine displays a favorable safety profile and results in greater treatment satisfaction in children compared with other second-generation antihistamines. This review aimed to evaluate and compare the safety and efficacy of fexofenadine with other available first- and second-generation antihistamines in children with AR.

allergy.org.au

australasian society of clinical immunology and allergy (ascia) is the peak professional body of allergists and clinical immunologists in australia and new zeal

ncbi.nlm.nih.gov

Search all biomedical databases provided by the National Center for Biotechnology Information (NCBI), an agency of the U.S. National Library of Medicine at the NIH