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nanomedicine-rj.com

Objective(s): The COVID-19 pandemic has underscored the global threat posed by opportunistic pathogens, including drug-resistant fungi. Metal nanoparticles are considered general microbicidal agents. These nanoparticles have a broad antimicrobial spectrum. Methods: The preparation of nanoparticles with curcumin coating was performed through a single-step procedure in which curcumin acted as a reducing and stabilizing agent. The characterizations of the particles were conducted through electron microscopy, dynamic light scattering, and UV-Vis spectroscopy. The cytotoxicity of particles was evaluated with an MTT assay. The antifungal properties of curcumin-coated gold nanoparticles were evaluated up to a concentration of 128 μg/ml against different species of Candida and Aspergillus, and compared with common antifungal drugs such as fluconazole and itraconazole. TEM was applied to investigate the structural analysis of the particles' interaction.Results: The particle synthesis was performed using a single-batch green method. Characterized by TEM, UV-Vis, and DLS, the particles exhibited an average diameter of 7.5 ± 4.1 nm and remained stable for over 64 days. Cytotoxicity tests on HepG2 cells showed high biocompatibility. While Cur@AuNPs exhibited antifungal activity against various species of Candida, including drug-resistant strains, no significant activity was observed against Aspergillus species. These findings suggest potential applications of Cur@AuNPs in treating Candida-related infections.Conclusions: Cur@AuNPs demonstrate inhibitory properties on different species of Candida but do not exhibit antifungal activity against either drug-sensitive or drug-resistant Aspergillus species.

sciencepublishinggroup.com

Social Media platforms are increasing user engagements with their attractive User Interfaces (UI) design playing a crucial role in maintaining user involvement. Use of Emotional Intelligence (EI) into the UI transforming user interaction and engagement pattern significantly. With an emphasis on how design decisions affect user behaviour, this study explores the nuanced function of EIUIs (Emotionally Inteligence User Interfaces) in the context of social media. It specifically draws attention to the dangers of manipulative techniques like "dark patterns"-purposeful interface strategies intended to influence users to take actions they might not have otherwise taken-as well as the possibility of constructive involvement. By investigating these practices, the paper hopes to clarify the wider ethical consequences of interface design as well as the duty of platforms and designers to promote transparency, autonomy, and confidence in digital interactions. This paper aims to contribute to the discourse on user interface design by providing a comprehensive understanding of EIUIs' potential and pitfalls in the context of social media interactions. Additionally, this study focusses on finding information of the pattern of Emotionally Intelligent User Interfaces (EIUI) design to enhance user engagements emotionally and tend to take decisions and the impact of the design pattern in user experience.

sci-hub.ru

sci-hub website. get free access to academic journals. download research papers for free from sciencedirect, ieee, wiley, springer, nature and others

omicsonline.org

OMICS Online is a platform offering open-access journals, conferences, and scientific content across various fields including medicine, biology, and technology.