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MELAS is a rare and serious genetic condition that affects how the body’s cells produce energy, leading to extreme fatigue, muscle weakness, and a range of other symptoms. With no cure currently available, treatment focuses only on managing complications. A team of researchers led by Dr Liisa Laakso at the Mater Research Institute-University of Queensland, Australia, is exploring an innovative, non-drug therapy called photobiomodulation, which uses light to stimulate mitochondria to work more efficiently. This pioneering study will provide intial evidence on whether PBM can safely reduce fatigue and improve quality of life for people living with MELAS, paving the way for future clinical trials.