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rheumatology.org

learn more about the american college of rheumatology, a non-profit, professional association committed to advancing the specialty of rheumatology. the acr serves nearly 9,100 physicians, health professionals, and scientists worldwide who work in the medical subspecialty of rheumatology.

jrheum.org

Objective. Anti-carbamylated protein (anti-CarP) antibodies could further elucidate early rheumatoid arthritis (RA) pathogenesis and predict clinical disease. We compared the diagnostic accuracy of anti-CarP antibodies for future RA to other RA-related antibodies in military personnel. Methods. Stored pre-RA diagnosis serum samples from 76 RA cases were tested for anti-CarP fetal calf serum (FCS), anti-CarP fibrinogen (Fib), anticyclic citrullinated peptide antibodies version 2 (anti-CCP2), rheumatoid factor-nephelometry (RF-Neph), and RF isotypes [immunoglobulin M (IgM), IgG, and IgA]. Positivity for all antibodies was determined as ≥ 2 SD of log-transformed means from controls. Relationships between autoantibodies and future RA were assessed in prediagnosis serum for all RA cases compared to controls using sensitivity, specificity, and logistic regression. Differences in diagnostic accuracy between antibody combinations were assessed using comparisons of area under the curves (AUC). Results. Anti-CarP-FCS was 26% sensitive and 95% specific for future RA, whereas anti-CarP-Fib was 16% sensitive and 95% specific for future RA. Anti-CarP-FCS positivity was associated with future RA, while anti-CarP-Fib trended toward association. The antibody combination of anti-CCP2 and/or ≥ 2 RF (RF-Neph and/or RF-isotypes) resulted in an AUC of 0.72 for future RA, where the AUC was 0.71 with the addition of anti-CarP-FCS to this prior combination. Conclusion. Adding anti-CarP-FCS to antibody combinations did not improve AUC. However, anti-CarP-FCS was associated with future onset of RA, and was present in prediagnosis serum in ∼10% of RA cases negative for anti-CCP2 but positive for RF.

healio.com

Advance your clinical knowledge and earn free CME credits online at Healio.com. Choose from hundreds of activities and print your CME certificates instantly.

amersa.org

AMERSA, founded in 1976, is a non-profit professional organization whose mission is to improve health and well-being through interdisciplinary leadership in substance use education, research, clinical care and policy.

ccrheumatology.com

Congress of Clinical Rheumatology Privacy Policy Your privacy and safety of your data is important to us. This Privacy Policy document describes types of information that is or may be collected, used or shared by www.ccrheumatology.com when you visit, use or make a purchases. If you have any additional questions or require more information about […]

swflrheum.com

Suffering from a rheumatic disorder? Learn about rheumatologists and their impact on rheumatic disease diagnosis & treatment.

argmd.net

Patient Education Frequently Asked Questions What is a Rheumatologist? A Board Certified rheumatologist is a specialized internal medicine physician who undergoes additional training focused on the diagnosis, management, and treatment of musculoskeletal conditions and systemic autoimmune diseases, collectively known as rheumatic diseases. These diseases affect joints, muscles, bones, and sometimes internal organs, causing symptoms such […]

bpna.org.uk

british paediatric neurology association