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reviewofophthalmology.com

review of ophthalmology highlights current, clinically relevant information on surgical techniques, disease diagnosis and management and new technologies

optometrytimes.com

Optometry Times delivers clinical news, practice insights, and research updates by optometrists for optometrists to advance care and patient outcomes.

eyewire.news

Get breaking ophthalmic news, device and drug updates, clinical trial coverage, thought-leader perspective, and industry announcements.

aao.org

In this video, Josh Gross, MD, discusses how  private, physician-led rural practice offers broad clinical and surgical scope, true autonomy, and deep community impact.

healio.com

Advance your clinical knowledge and earn free CME credits online at Healio.com. Choose from hundreds of activities and print your CME certificates instantly.

tctmd.com

Guidelines still contain strong recommendations for aspirin’s use, but some are calling for new trials to confirm benefits.

eneuro.org

Recently developed probes for extracellular electrophysiological recordings have large numbers of electrodes on long linear shanks. Linear electrode arrays, such as Neuropixels probes, have hundreds of recording electrodes distributed over linear shanks that span several millimeters. Because of the length of the probes, linear probe recordings in rodents usually cover multiple brain areas. Typical studies collate recordings across several recording sessions and animals. Neurons recorded in different sessions and animals thus have to be aligned to each other and to a standardized brain coordinate system. Here, we evaluate two typical workflows for localization of individual electrodes in standardized coordinates. These workflows rely on imaging brains with fluorescent probe tracks and warping 3D image stacks to standardized brain atlases. One workflow is based on tissue clearing and selective plane illumination microscopy (SPIM), whereas the other workflow is based on serial block-face two-photon (SBF2P) microscopy. In both cases electrophysiological features are then used to anchor particular electrodes along the reconstructed tracks to specific locations in the brain atlas and therefore to specific brain structures. We performed groundtruth experiments, in which motor cortex outputs are labeled with ChR2 and a fluorescence protein. Light-evoked electrical activity and fluorescence can be independently localized. Recordings from brain regions targeted by the motor cortex reveal better than 0.1-mm accuracy for electrode localization, independent of workflow used.

pubmed.ncbi.nlm.nih.gov

Gates Foundation, St Jude Children's Research Hospital.

nature.com

Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest ...

linkedin.com

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