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$50M PROGRAM MCPsych Multi-Channel Psych (MCPsych) aims to develop an integrated model of anhedonic depression that captures both internal biological factors and externally-manifested, quantifiable measures. The program also seeks to reveal biological mechanisms of anhedonia by synchronizing investigations across genes, molecules, cells, animal models, and humans.https://wellcomeleap.org/wp-content/uploads/2025/10/the_story_of_mcpsych_captioned-720p.mp4 Depression is a complex biological illness. We need treatments to match. Why are we stuck? The latest survey of global health underscores the devastating impact of depression. Depression was ranked as the 3rd highest cause of disability across all illnesses, resulting in approximately 43 million years lost to disability. In only a single year, 264 million people suffer from depression, and 800,000 lives are lost to suicide.NIH has spent over $22 billion on depression research over the last 20 years – more than for any other mental illness, including addiction, schizophrenia, or autism. But despite this massive investment, only 1 in 3 patients substantially responds to currently available treatments.Rapid stratification and patient-specific matching to the most promising treatment option would reduce adverse effects and prevent progression. Currently 33% of depressed people have significant symptom reduction with the initial treatment selected, while an additional 21-33% of people require between 2-4 treatment trials to achieve remission. MCPsych has the goal of doubling the number of people who receive an effective treatment on the first try. In addition, the program seeks to reveal mechanistic understanding sufficient to identify effective treatments for half of non-responsive patients and have the same impact on the survivability of severe, treatment-resistant depression that advances in diagnostics and treatment have had on the survivability of certain cancers. Namely, that in the future, it

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