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arpnjournals.org

arpn is publishing open access peer-reviewed research journals in the fields of engineering, technology, agricultural and biological sciences

ijllr.com

IJLLR Journal is an online bi-annual Law journal. The Journal revolves around Socio-legal Topics and is not restricted to any particular field or subject of law. The Journal promotes interdisciplinary research entailing detailed study of law with other disciplines in the contemporary era.

actagastro.org

Luis Florez Bracho, Silvina Paz, Astrid Rausch, Juan Lasa, Alejandro Dutack, Ignacio Zubiaurre Servi

bmjmedicine.bmj.com

Objective To compare routine high risk human papillomavirus (hrHPV) screening with cytological screening in two screening rounds in a well established, routine screening programme for cervical cancer.Design Population based cohort study.Setting Finland’s Mass Screening Registry, 2012-22, with diagnostic follow-up examinations until October 2024.Participants 1 180 491 women participating at least once in cytological test (PAP smear) or hrHPV based cervical cancer screening between 2012 and 2022.Main outcome measures Numbers and proportions of attendees, positive routine test results, follow-up screening referrals, colposcopy referrals, and incidence of cervical intraepithelial neoplasia ≥grade 2 (CIN2+) in the first and second hrHPV and cytological screening rounds. Results adjusted for age, year, region, and education.Results Data for 1 574 688 full screening rounds were analysed. The overall referral rate for colposcopy was 3.37% (n=12 273) in the hrHPV group and 0.98% (n=11 895) in the cytology group, with an adjusted risk ratio of 2.97 (95% confidence interval (CI) 2.87 to 3.07). The overall rate for detection of CIN2+ was 0.92% in the hrHPV group and 0.35% in the cytology group, with an adjusted risk ratio of 2.17 (2.04 to 2.31). For the second hrHPV screening round compared with the first screening round, the adjusted risk ratio was 0.77 (0.71 to 0.84) for referral for colposcopy and 0.57 (0.46 to 0.72) for detection of CIN2+. Actual rates for referral for colposcopy were 3.54% (n=11 709) in the first hrHPV screening round and 2.42% (n=564) in the second screening round. The rate for detection of CIN2+ for hrHPV screening was 0.98% (n=3 248) in the first hrHPV screening round and 0.38% (n=88) in the second screening round. In cytological screening, no observed reduction was seen in either the referral rate or CIN2+ findings. After a negative hrHPV test in the first screening round, CIN2+ was detected in only 0.2% of women (n=44/314 286) in the second screening

abc-citations.com

Découvrez plus de 50 citations de Boris Cyrulnik, psychiatre et éthologue français.

mattioli1885journals.com

La Medicina del Lavoro

drugdiscoverynews.com

Discover why mass photometry is becoming essential in the toolbox of protein studies.

researchgate.net

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