Top 10 jneurosci.org Wettbewerber

eneuro.org

Recently developed probes for extracellular electrophysiological recordings have large numbers of electrodes on long linear shanks. Linear electrode arrays, such as Neuropixels probes, have hundreds of recording electrodes distributed over linear shanks that span several millimeters. Because of the length of the probes, linear probe recordings in rodents usually cover multiple brain areas. Typical studies collate recordings across several recording sessions and animals. Neurons recorded in different sessions and animals thus have to be aligned to each other and to a standardized brain coordinate system. Here, we evaluate two typical workflows for localization of individual electrodes in standardized coordinates. These workflows rely on imaging brains with fluorescent probe tracks and warping 3D image stacks to standardized brain atlases. One workflow is based on tissue clearing and selective plane illumination microscopy (SPIM), whereas the other workflow is based on serial block-face two-photon (SBF2P) microscopy. In both cases electrophysiological features are then used to anchor particular electrodes along the reconstructed tracks to specific locations in the brain atlas and therefore to specific brain structures. We performed groundtruth experiments, in which motor cortex outputs are labeled with ChR2 and a fluorescence protein. Light-evoked electrical activity and fluorescence can be independently localized. Recordings from brain regions targeted by the motor cortex reveal better than 0.1-mm accuracy for electrode localization, independent of workflow used.

pnas.org

proceedings of the national academy of sciences (pnas), a peer reviewed journal of the national academy of sciences (nas) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.

elifesciences.org

In this episode, we hear about the potential of synthetic gene circuits to target cancer, a zebrafish model of cerebral small vessel disease, evidence that psilocybin may alleviate depression, a new technique to make flu vaccines more effective, and why crabs walk sideways.

frontiersin.org

Explore open access research in comparative governance, comparing political systems, institutions and public administration.

biorxiv.org

biorxiv - the preprint server for biology, operated by cold spring harbor laboratory, a research and educational institution

nature.com

Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest ...

cell.com

publisher of over 50 scientific journals across the life, physical, earth, and health sciences, both independently and in partnership with scientific societies including cell, neuron, immunity, current biology, ajhg, and the trends journals.

sciencedirect.com

sciencedirect is the world's leading source for scientific, technical, and medical research. explore journals, books and articles.

journals.plos.org

Learn more about our institutional models for librarians and the benefits for researchers.

pubmed.ncbi.nlm.nih.gov

Gates Foundation, St Jude Children's Research Hospital.