Wellbutrin is a medication with the active ingredient bupropion. It is also known by other names like Zyban and Aplenzin. Wellbutrin is used to treat depression and to help people quit smoking. It works by affecting chemicals in the brain that contribute to mood and cravings. Wellbutrin Price Expect to pay anywhere from £1.42 to £1.98 for a pills of Wellbutrin. The disparity in cost arises from packaging volume and the grade of active ingredients (20 or 360 mg). Medication Overview Wellbutrin, also known as Bupropion, is an antidepressant medication primarily used to treat major depressive disorder (MDD) and seasonal affective disorder (SAD). It is an atypical antidepressant and differs from other antidepressants such as SSRIs and SNRIs. It enhances certain neurotransmitters in the brain to exert its therapeutic effects. Mechanism of Action Wellbutrin functions by inhibiting the reuptake of norepinephrine and dopamine, two neurotransmitters linked to mood regulation. This inhibition results in increased levels of these neurotransmitters in the synaptic cleft, which helps alleviate symptoms associated with depression. The exact mechanism of action is not fully understood, but it is known to have minimal effects on serotonin reuptake. Dosage Forms Wellbutrin is available in three primary dosage forms: immediate-release (IR), sustained-release (SR), and extended-release (XL). The IR formulation is generally taken three times a day, the SR formulation is typically taken twice daily, and the XL formulation is taken once daily. Dosage adjustments are often required based on individual patient needs and responses. Indications For Use Wellbutrin is indicated for the treatment of major depressive disorder (MDD) and seasonal affective disorder (SAD). It is also prescribed as an aid for smoking cessation under the brand name Zyban. It is sometimes used off-label for conditions such as attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder, although these uses