Top 10 medcraveonline.com Competitors

medcrave.com

medcrave home

jscimedcentral.com

jscimed central provides scientific medical journals & research papers open access pdf download. publish quality peer-reviewed journals in science field.

medwinpublishers.com

Obesity is a multifactorial global health concern strongly associated with metabolic disorders, including type 2 diabetes mellitus, cardiovascular diseases, and metabolic syndrome. Genetic determinants, particularly polymorphisms in the PPARγ and TRHR genes, have been implicated in susceptibility to obesity across diverse populations. This study aimed to investigate the genotype distributions of PPARγ (rs1801282) and TRHR (rs16892496) polymorphisms and to evaluate their associations with metabolic parameters in a Turkish cohort. Genotyping was performed using real-time polymerase chain reaction in a total of 239 individuals, comprising 160 patients with obesity and/or diabetes and 79 healthy controls. In the non-diabetic obese subgroup, individuals carrying the GG genotype showed significantly different body mass index (BMI) values compared with those carrying the CC and CG genotypes (p = 0.008). In the control group, carriers of the C allele exhibited significantly higher high-density lipoprotein (HDL) cholesterol levels than carriers of the G allele (p = 0.034). Furthermore, BMI values were significantly lower in A allele carriers compared with C allele carriers within the control group (p = 0.026). These findings suggest that genetic variation in PPARγ and TRHR may contribute to obesity- and diabetes-related phenotypes and could influence disease susceptibility. However, further large-scale, multi-ethnic studies are warranted to validate these associations and elucidate the underlying molecular mechanisms.

sciencedirect.com

sciencedirect is the world's leading source for scientific, technical, and medical research. explore journals, books and articles.

pubmed.ncbi.nlm.nih.gov

Gates Foundation, St Jude Children's Research Hospital.

researchgate.net

Access 160+ million publication pages and connect with 25+ million researchers. Join for free and gain visibility by uploading your research.

nature.com

Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest ...

mdpi.com

MDPI is a publisher of peer-reviewed, open access journals since its establishment in 1996.

jnnp.bmj.com

A peer-reviewed neurology, neurosurgery and psychiatry journal publishing the latest research and reviews on the entire genre of neurological sciences.