Top 10 sciltp.com Competitors

medwinpublishers.com

Obesity is a multifactorial global health concern strongly associated with metabolic disorders, including type 2 diabetes mellitus, cardiovascular diseases, and metabolic syndrome. Genetic determinants, particularly polymorphisms in the PPARγ and TRHR genes, have been implicated in susceptibility to obesity across diverse populations. This study aimed to investigate the genotype distributions of PPARγ (rs1801282) and TRHR (rs16892496) polymorphisms and to evaluate their associations with metabolic parameters in a Turkish cohort. Genotyping was performed using real-time polymerase chain reaction in a total of 239 individuals, comprising 160 patients with obesity and/or diabetes and 79 healthy controls. In the non-diabetic obese subgroup, individuals carrying the GG genotype showed significantly different body mass index (BMI) values compared with those carrying the CC and CG genotypes (p = 0.008). In the control group, carriers of the C allele exhibited significantly higher high-density lipoprotein (HDL) cholesterol levels than carriers of the G allele (p = 0.034). Furthermore, BMI values were significantly lower in A allele carriers compared with C allele carriers within the control group (p = 0.026). These findings suggest that genetic variation in PPARγ and TRHR may contribute to obesity- and diabetes-related phenotypes and could influence disease susceptibility. However, further large-scale, multi-ethnic studies are warranted to validate these associations and elucidate the underlying molecular mechanisms.

intereconomics.eu

Intereconomics is an academic journal that publishes articles by experts on current economic and social policy issues affecting Europe.

bmjopengastro.bmj.com

Objectives Acute severe ulcerative colitis (ASUC) poses challenges to patient management owing to its high surgical rate. This study aimed to identify predictors of colectomy in patients with ASUC.Design This is a systematic review and meta-analysis.Data sources PubMed and Web of Science were searched up to April 2024.Eligibility criteria Studies on the predictors of colectomy in adult patients with ASUC were eligible.Data extraction and synthesis Two reviewers independently extracted the data using a prespecified data collection sheet. A qualitative synthesis was performed in tabular form. Random-effect meta-analyses were conducted using OR and 95% CI.Results Forty-two studies were included in the systematic review. The reported variables can be categorised into biomarkers, auxiliary examination findings, demographic and clinical characteristics, and drug factors. Through meta-analysis, albumin (OR 0.39 (95% CI 0.26 to 0.59) per 1 g/dL increment, I 2=0.0%), high C reactive protein level (2.63 (1.53 to 4.52), I2=29.6%), high erythrocyte sedimentation rate level (2.92 (1.39 to 6.14), I2=0.0%), low haemoglobin level (2.08 (1.07 to 4.07), I2=56.4%), fulfilling the Oxford criteria (4.42 (2.85 to 6.84), I2=0.0%), extensive colitis (1.85 (1.24 to 2.78), I2=47.5%), previous steroids (1.75 (1.23 to 2.50), I2=17.7%) or azathioprine (2.25 (1.28 to 3.96), I2=0.0%) use, and sarcopenia (1.90 (1.04 to 3.45), I2=0.0%) were identified as valuable predictors for colectomy within 1 year. The ulcerative colitis endoscopic index of severity (OR 2.41 (95% CI 1.72 to 3.39), I2=1.5%) was the only predictor found to predict colectomy over 1 year.Conclusion Identification of these predictors may facilitate risk stratification of patients with ASUC, drive personalised treatment and reduce the need for colectomy.

nuvotronics.com

Industry-leading RF and mmWave solutions with smaller size, lower weight, and superior performance for satellite, telecom, electronic warfare, and test applications.

fremdwort.de

fremdwort.de ist Ihr Fremdwörterbuch, Wissensportal und Wörterbuch mit über 1.000.000 der wichtigsten Fremdwörter, Wörter und deren Bedeutung.

nmn.com

Among healthy aging enthusiasts, plasma exchange therapy is gaining popularity as a way to possibly remove toxins from blood plasma and enhance longevity.

blackfacts.com

While incarcerated in Luzira Maximum Security Prison in Kampala, she wrote the collection No Roses from My Mouth: Poems from Prison. She dedicated the poems to all women locked up in prisons in Uganda and the world over. Some of the poems that were ...

meigenmeikan.com

ウチらは互いに、自分の過去を嫌っとる・・・。ウチにもあるんや・・・「今際の国」に来てからも、どんなに死の瀬戸際に立たされ