Top 10 e-jwj.org Wettbewerber

sciexplor.com

Disulfidptosis is a recently identified form of regulated cell death (RCD) triggered by disulfide stress when cystine uptake via solute carrier family 7 member 1 (SLC7A11) overwhelms the cell’s reducing capacity. Unlike apoptosis or other “cell suicide” pathways, disulfidptosis likely represents a “cell sabotage” mechanism, defined by aberrant disulfide bonding and catastrophic actin cytoskeleton collapse. In this Perspective, we examine the paradoxical role of SLC7A11 as both a ferroptosis protector and a disulfidptosis trigger, and the mechanistic hallmarks of disulfidptosis. We highlight emerging therapeutic strategies to target disulfidptosis in cancer, including glucose transporter inhibition, redox-targeting agents, and nanomaterial-based approaches, and consider its dual role in immunity, where it may suppress T cell function yet act as a form of immunogenic cell death. Together, these insights position disulfidptosis as both a conceptual advance in RCD biology and a promising target for cancer therapy that warrants further mechanistic and translational exploration.

historystudies.net

history studies international journal of history

revista.abrale.org.br

Conteúdo gratuito para pacientes de câncer e doenças do sangue, e seus familiares. Matérias sobre linfoma, leucemia, bem-estar e muito mais!

worldwar1.com

comprehensive information on the first world war of 1914-1918: trenches on the web and doughboy center sites; st. mihiel trip-wire newsletter, over the top magazine; & roads to the great war blog.

edu.cctv.com

教育变革+国际理解