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jmir.org

Journal of Medical Internet Research - International Scientific Journal for Medical Research, Information and Communication on the Internet

researchprotocols.org

JMIR Research Protocols

publicationethics.org

promoting integrity in scholarly research and its publication

ochsnerjournal.org

Background Surgical manipulation in the sinonasal cavity may transiently increase airflow resistance in patients with obstructive sleep apnea (OSA), predisposing them to inspiratory collapse of the oropharynx and/or hypopharynx. We hypothesized that patients with OSA undergoing sinonasal surgery would have higher rates of unplanned postoperative admission and respiratory complications than patients without OSA. Methods In this retrospective cohort study, patients ≥18 years undergoing sinonasal surgery were compared to patients having oropharyngeal, laryngeal, otologic, rotator cuff, and inguinal hernia surgery between January 2013 and December 2020. Cohorts were defined by the presence or absence of a preoperative diagnosis of OSA. All outcome variables were measured based on unique patient encounters for surgery; the total number of surgeries for the overall patient population (n=17,373) was greater than the total number of patients (n=11,951). Results Study groups consisted of 4,575 sinonasal, 2,301 oropharyngeal, 1,231 laryngeal, 1,353 otologic, 434 rotator cuff, and 2,057 inguinal hernia surgical patients. Among patients undergoing sinonasal surgery, patients with OSA had more unplanned admissions than patients without OSA (risk ratio [RR] 3.12; 95% CI 2.07-4.70). In all surgery groups, postoperative supplemental oxygen therapy was required more often in patients with OSA. Patients with OSA had the greatest incidence of oxygen desaturation after oropharyngeal surgery (RR 1.95; 95% CI 1.34-2.85). Incidence of 30-day readmission did not differ between patients with and without OSA in any surgical group. Conclusion In this study, patients with OSA undergoing sinonasal surgery had a greater risk of unplanned hospital admission than patients without OSA, and patients with OSA undergoing oropharyngeal surgery had a greater risk of postoperative desaturation than patients without OSA. Patients with OSA undergoing any surgery had a greater incidence of supplemental o

scienceopen.com

Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the resulting coronavirus disease 2019 (Covid-19) have afflicted tens of millions of people in a worldwide pandemic. Safe and effective vaccines are needed urgently. Methods In an ongoing multinational, placebo-controlled, observer-blinded, pivotal efficacy trial, we randomly assigned persons 16 years of age or older in a 1:1 ratio to receive two doses, 21 days apart, of either placebo or the BNT162b2 vaccine candidate (30 μg per dose). BNT162b2 is a lipid nanoparticle–formulated, nucleoside-modified RNA vaccine that encodes a prefusion stabilized, membrane-anchored SARS-CoV-2 full-length spike protein. The primary end points were efficacy of the vaccine against laboratory-confirmed Covid-19 and safety. Results A total of 43,548 participants underwent randomization, of whom 43,448 received injections: 21,720 with BNT162b2 and 21,728 with placebo. There were 8 cases of Covid-19 with onset at least 7 days after the second dose among participants assigned to receive BNT162b2 and 162 cases among those assigned to placebo; BNT162b2 was 95% effective in preventing Covid-19 (95% credible interval, 90.3 to 97.6). Similar vaccine efficacy (generally 90 to 100%) was observed across subgroups defined by age, sex, race, ethnicity, baseline body-mass index, and the presence of coexisting conditions. Among 10 cases of severe Covid-19 with onset after the first dose, 9 occurred in placebo recipients and 1 in a BNT162b2 recipient. The safety profile of BNT162b2 was characterized by short-term, mild-to-moderate pain at the injection site, fatigue, and headache. The incidence of serious adverse events was low and was similar in the vaccine and placebo groups. Conclusions A two-dose regimen of BNT162b2 conferred 95% protection against Covid-19 in persons 16 years of age or older. Safety over a median of 2 mont

springernature.com

we are a global publisher dedicated to providing the best possible service to the whole research community. we help authors to share their discoveries; enable researchers to find, access and understand the work of others and support librarians and institutions with innovations in technology and data.

ijcsmc.com

IJCSMC is a Double-Blind Peer Reviewed Fully Refereed Computer Science Journal | Yes, IJCSMC is legit and IJCSMC is trusted by millions of researchers worldwide

academia.sg

Philip Holden conceptualises intellectual history in Singapore through the writings of Singaporean statesman S. Rajaratnam.