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Ipamorelin + CJC-1295 — Complementary GH Axis Research Blend This combo pairs Ipamorelin (a selective ghrelin/GHSR-1a agonist) with CJC-1295 (a GHRH analogue, ±DAC). Together they’re used to study pituitary growth-hormone (GH) pulsatility, hypothalamic–pituitary regulation, and downstream IGF-1 biology in controlled research settings. Component A — Ipamorelin CAS: 170851-70-4  PubChem CID: 9831659  Sequence (pentapeptide): Aib-His-D-2-Nal-D-Phe-Lys-NH2  Notes: Highly selective for GH release with minimal ACTH/cortisol or prolactin effects vs older GHRPs.  Component B — CJC-1295 (GHRH analogue) Forms: CJC-1295 with DAC (albumin-binding “Drug Affinity Complex”) and CJC-1295 no DAC / Mod GRF(1-29). CAS (reported): with DAC 446262-90-4 ; no-DAC listings vary by substitution, commonly 446036-97-1 or 863288-34-0.  Mechanism: Agonist at the GHRH receptor (GHRHR) on pituitary somatotrophs. PK note: DAC prolongs half-life via albumin binding; no-DAC behaves like short-acting GHRH(1-29) analogues. Why Use the Combo (Plain English) Two switches, one output: CJC-1295 triggers the pituitary via GHRH, while Ipamorelin stimulates the ghrelin/GHSR pathway. Hitting both can amplify GH pulses vs either alone (synergy shown with GHRH + GHRPs/ghrelin).  Clean signal: Ipamorelin is noted for selective GH release with low cortisol/prolactin cross-activation in studies—helpful for tidy readouts.  Design flexibility: Choose no-DAC (short-acting pulses) or DAC (sustained exposure) to match your protocol window. Key Study Themes — What’s Typically Tested GHRH + GHS synergy on GH pulsatility What’s tested: Co-administration of a GHRH analogue with a ghrelin mimetic; serial GH sampling and deconvolution analysis. What changes: Greater peak GH and area-under-curve vs either agent alone in human and animal models.  Why it matters: Models how dual hypothalamic inputs coordinate pituitary output, informing endocrine physiology and test paradigms.  Selectivity &am

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penguinpeptides.com

Penguin Peptides LLC (Wyoming)Effective Date: 2/15/2026 Penguin Peptides LLC (“Company”, “we”, “us”, or “our”) respects your privacy and is committed to protecting your personal information. This Privacy Policy describes how we collect, use, disclose, and safeguard your information when you visit our website or purchase research products. By using our website, you consent to the