Top 10 childrenshospital.org Competitors

chop.edu

Allan-Herndon-Dudley syndrome (AHDS) — also known at MCT8 deficiency — is a rare genetic disorder that affects a child’s cognition, mobility and overall health. What is MCT8 deficiency?Allan-Herndon-Dudley syndrome (AHDS) — also known at MCT8 deficiency — is a rare genetic disorder that affects a child’s cognition, mobility and overall health. In individuals with AHDS, thyroid hormone is unable to enter cells in the brain because of a defect in a thyroid hormone transporter called MCT8. Thyroid hormones are particularly important for proper brain development during pregnancy and early childhood.At the same time, excess thyroid hormone, specifically T3 (triiodothyronine), enter tissues in the rest of the body, which typically leads to life-threatening complications. The result is that patients are born with permanent and severe developmental delay from hypothyroidism (not enough thyroid hormone) in the brain while at the same time they experience hyperthyroidism (too much thyroid hormone) in the rest of their body, leading to intellectual disability, decreased muscle tone, disorganized movements, restless sleep, increased heart rate (tachycardia), failure to thrive/inability to gain weight, and, ultimately, severe infection and cardio-respiratory failure.AHDS is an X-linked genetic disorder with a 50% chance that male babies will have the disorder if their mother is a carrier of the abnormal gene that codes for the MCT8 thyroid hormone transporter protein. Although not well described, female carriers of the MCT8 gene may also have symptoms, often more mild although several females have had more severe symptoms similar to males. The disorder may also develop spontaneously during fetal development, where the baby is the first person in the family to have AHDS.Signs and symptoms of MCT8 deficiencyThere are several signs/symptoms of MCT8 deficiency. They include:Appearance – Patients may have a longer and more narrow face compared to other family members. Patients may al

cincinnatichildrens.org

caring for infants to adolescents, cincinnati children's hospital medical center is an international leader in pediatric medicine, research and education.

nationwidechildrens.org

nationwide children's hospital is one of the largest and most comprehensive pediatric hospitals and research institutes in the united states.

stanfordchildrens.org

stanford medicine children’s health is the only network in the area—and one of the few in the country—exclusively dedicated to pediatric and obstetric care.

texaschildrens.org

Our mission is to create a healthier future for children and women throughout our global community by leading in patient care, education and research.

childrensnational.org

Learn about the Children's National terms of use.

childrenscolorado.org

Your guide for all things baby

stlouischildrens.org

Information on selective dorsal rhizotomy (SDR), a treatment for spastic cerebral palsy in children. Learn more from the Center for Cerebral Palsy Spasticity at St. Louis Children's Hospital. For a physician referral, call 314.454.5437.

seattlechildrens.org

Seattle Children’s (Children’s) privacy policy.

luriechildrens.org

Lurie Children’s is not only focused on treating children’s illnesses, but we are also committed to making sure our patients and their families are supported mentally, emotionally and spiritually.