Acceleration of worldwide infection with mutant of coronavirus SARS CoV-19 require new paradigmatic of human activity based on negative feed-back system following basic mechanism of Homeostasis of all living organisms and ecosystems. Condition of efficient primary prevention is better integration of cooperation of interdisciplinary teams of experts, knowledge-based society and decision-makers on local scale with working global network focused on common action for efficient protection against contamination of the Human environment with mutagens for reduction risk of incidence new mutants [Ex: Coronaviruses and new pandemics]. Key factor for primary prevention is reduction at the sources emission of immune suppressors, carcinogens and teratogens. Efficient prevention is depended on without delay worldwide introduction of complementary good practice in innovative environmental biotechnology integrated with ecological engineering and circular bioeconomy-driven sustainable development adopted to different kind of regions. Let us recommend heuristic approach, better financial support of transdisciplinary innovative basic and research-developing studies, improvement application of new IT tools for speed dissemination of scientific and technical progress, elimination of bureaucratic barriers and progress in distance problem-solving training and lifelong learning focused on sustainable, knowledge-based society selecting decision-makers with proper imagination and responsibility. Introduction on wider scale innovative biotechnologies [Ex: Recommended by our team modern environmental ecological engineering integrated with renewable sources of energy, laser biotechnology for better adaptation to climate change, aquaculture, apiculture etc.] focused on better prevention against contamination of the air, water and food; would be beneficial for environmental health. It would be also useful for creation in the near future many green jobs all over the world and for reduction risk of