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preprints.org

Background: Recent trials, including JCOG0802/WJOG4607L and CALGB140503, con-firmed the oncological adequacy of segmentectomy for early-stage non-small cell lung cancer (NSCLC). This shift emphasizes the preservation of pulmonary function and minimal invasiveness. Robot-assisted thoracic surgery (RATS) offers enhanced anatomi-cal precision and potentially improves segmentectomy outcomes. Methods: We reviewed the current evidence comparing sublobar resection and lobectomy for early-stage NSCLC, focusing on RATS segmentectomy. Clinical trials, perioperative and long-term outcomes, technical innovations, and patient selection criteria were analyzed. Comparative data among RATS, video-assisted thoracoscopic surgery (VATS), and open approaches were synthesized, including the emerging roles of AI and 3D imaging. Results: Segmentectomy yields survival outcomes equivalent or superior to lobectomy for stage IA peripheral NSCLC ≤2 cm, with better pulmonary function despite higher locoregional recurrence. RATS enhances visualization, dexterity, and ergonomics, thereby enabling precise dissec-tion and lymph node assessment. Compared to VATS and open surgery, RATS shows lower conversion rates, reduced pain, and comparable oncological control. Innovations, such as indocyanine green imaging, 3D modeling, and AI-guided navigation, support margin accuracy and personalized care. Conclusions: Segmentectomy has redefined the surgical standards for early-stage NSCLC. RATS maximizes the minimally invasive bene-fits by combining oncological safety and functional preservation. Its technical precision facilitates complex resections and integration with digital planning tools to advance per-sonalized thoracic surgery. RATS represents the next evolution of minimally invasive thoracic surgery, redefining the balance between oncological safety and functional preservation in early-stage NSCLC.

annalsofglobalhealth.org

annals of global health is a peer-reviewed, fully open access, online journal dedicated to publishing high quality articles dedicated to all aspects of global health. the journal's mission is to advance global health, promote research, and foster the prevention and treatment of disease worldwide. its goals are to improve the health and well-being of all people, advance health equity, and promote wise stewardship of the earth's environment. the latest journal impact factor is 2.90. annals of global health is supported by the program for global public health and the common good at boston college. it was founded in 1934 by the icahn school of medicine at mount sinai as the mount sinai journal of medicine. it is a partner journal of the consortium of universities for global health.  from time to time, annals of global health publishes special collections, a series of articles organized around a common theme in global health. recent special collections have included "local evidence and strategies in addressing ncds non-communicable diseases in tanzania", "universal health coverage through integrated care", and "the minderoo-monaco commission on plastics and human health". global health workers interested in developing a special collection are strongly encouraged to contact the managing editor in advance to discuss the project.

knepublishing.com

KnE Open is an open access research platform, hosting groundbreaking new research from the medical, life sciences, social sciences, and humanities fields